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Abstract Angiogenesis is a vital process for the growth and dissemination of solid cancers

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The compound has been around for half a century with a substantial global safety record

At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling ( According to reports, these natural compounds have both direct and indirect antioxidant effects