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Sequence analyses have revealed that susceptibility is not conferred by major structural mutations, but rather by subtle variations in the peptide-binding grooves of MHC molecules that affect the presentation of self-antigens and promote autoreactivity (32)
Duarte D., Guerreiro I., and Vale N., Novel Strategies for Cancer Combat: Drug Combination Using Repurposed Drugs Induces Synergistic Growth Inhibition of MCF7 Breast and HT29 Colon Cancer Cells, Current Issues in Molecular Biology 44 (2022): 49304949
doi: 10.2337/dc16-0836 70 NachnaniJSBulchandaniDGNookalaAHerndonBMolteniAPandyaPet al
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![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
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