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Data collected from a randomized, placebo-controlled, double-blind trial of liraglutide 3.0 mg, in which nausea was the most frequent adverse event, showed that greater weight loss was associated with transient nausea and vomiting in participants with obesity but without diabetes [50]
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A single injection of 4, 8, or 16 mg of PEGylated GLP-1:GIP co-agonist in healthy humans increased insulin secretion and lowered blood glucose levels when administered 72 h prior to a graded glucose infusion challenge [77]
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