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In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)

13,14 In addition, the treatment effects on HE improvement (RR: 0.63) and mortality (RR: 0.49) from this meta-analysis indicate that a large proportion of patients with HE did improve despite treatment with NADs

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If you are experiencing increased cold sensitivity whilst taking Ozempic, there are several practical strategies that may help improve comfort without compromising the therapeutic benefits of the medication: Dress appropriately: Layer clothing to trap warm air close to the body