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Volatile oils obtained from the rhizomes of Chuanxiong and Danggui are rich in senkyunolides, yet they exhibit limited water solubility and poor oral bioavailability

In complex chronic conditions like Long COVID and ME/CFS, this initial acute depletion triggers a vicious, self-perpetuating cycle of cellular dysfunction

Known inhibitors of TGRs/TrxRs, which include metal complexes and compounds containing Michael acceptors or oxadiazole oxides 19,23,24 , usually react with Sec and Cys residues and other biogenic nucleophiles irreversibly