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Because MOTS-c is naturally produced in response to exercise, and because it activates the same AMPK and mitochondrial biogenesis pathways that exercise training upregulates, combining exogenous MOTS-c with a structured exercise program creates a reinforcing signal that operates through the same biological channels

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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

Finding the right balance with 2mL for 10mg provides optimal results