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The drug was approved by the US FDA in June 2021 as a 2.4 mg once-weekly injection for chronic weight management in adults with obesity or those overweight with at least one weight-related condition, such as high blood pressure, Type 2 diabetes or high cholesterol.3 In 2023, according to market information from Midas (IQVIA), sales of semaglutide for weight management more than quadrupled year-on-year, and further interest has been spurred by new indications related to reducing cardiovascular risk, and emerging benefits are being shown in people with Alzheimers disease.4,5 The strength of these figures clearly demonstrates the intense demand for GLP-1 treatments, but it does not convey the unforeseen implications of such high levels of popularity

Notably, obesity in school-aged children increased from 8.5% to 19% in just 10 years (2010-2020)

Prior Exercise in Humans Redistributes Intramuscular GLUT4 and Enhances Insulin-Stimulated Sarcolemmal and Endosomal GLUT4 Translocation. Krentz, Nicole A

Glucagon-like peptide-1 receptor agonists and risk of acute pancreatitis in patients with type 2 diabetes