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Additionally, the ongoing shortages of branded drugs made patients to shift towards compounding pharmacies providing their own version of drugs which made the government to impose compounding restrictions on GLP-1 receptor agonists (GLP-1 RA) owing to the lack of regulatory supervision of compounded versions and rising safety concerns for preventing serious adverse events and hospitalization of patients

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Thus, intercepting critical metabolic pathways that deplete T RM may be promising, such as trimetazidine, which blocks mitochondrial -oxidation of FFA and reduces T RM lifespan in the skin (128)