In 2012, while investigating the mechanism of Erastin-induced cell death, Dixon and colleagues formally coined the term ferroptosis to describe this iron-dependent, lipid peroxidation-mediated form of regulated cell death ( Compared with other forms of cell death, such as autophagy, apoptosis, and pyroptosis, ferroptosis exhibits distinct morphological, biochemical, and immunological characteristics (Xia et al., 2025)
Tumour tissues (100500 mg) were dissected into smaller fragments to cover the filter surface of 0.22 m nylon-filtered microcentrifuge tubes (Corning, 8160), taking care to minimize mechanical cell lysis
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