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The relationship between GLP-1 and Ozempic is explained in our detailed guide

Adjusting Your Dosage For some patients, it may be appropriate to increase the GLP-1 dosage, especially for those who are closer to the beginning of their treatment

10.1016/j.psyneuen.2014.03.013 [DOI] [PubMed] [Google Scholar] Rebosio C, Balbi M, Passalacqua M, Ricciarelli R, Fedele E (2018) Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus

Tirzepatide effectiveness can plateau as the body adapts, which is why the titration schedule exists, to increase the dose as tolerance develops