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Older anti-obesity medications such as orlistat functioned mainly through local gastrointestinal mechanisms, inhibiting fat absorption and resulting in a weight loss of 23% (Bansal et al

Thyroid Issues : Conditions like hypothyroidism can slow metabolism, making weight loss more challenging

Thus, it is expected that hypoalbuminemia will not, to any relevant extent, reduce the albumin-bound fraction of semaglutide further and will therefore also have negligible influence on the semaglutide pharmacokinetic profile after IcoSema administration

Chronic Weight Management (Wegovy) Semaglutide is also available under the brand name Wegovy for chronic weight management