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The G i protein inhibitor pertussis toxin (PTX) did not affect DRD2 activation-induced PKM2 dimerization, suggesting that PKM2 dimerization is independent of the classical G protein pathway (Fig

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The addition of DPP-4 inhibitors to patients already treated with metformin may seem particularly attractive, since both drugs may act to enhance circulating levels of GLP-1 and thus, may have synergistic effects on incretin receptor signaling [44,45,46]