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GRP75 is known as a marker of thermogenic adipocytes (Zhuang et al., 2025)

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This can be an important consideration as one could argue that patients taking GLP-1RAs might differ, compared with patients not on these medications, in their likelihood to have seen an eye care clinician. The commentary encouraged others to take a critical look at the designs and database limitations to understand how confounding, bias and chance may explain discrepancies in studies that rely on large databases