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Although PPIs are used worldwide to treat acid-related disorders, their excessive consumption can lead to disruption of microbial community composition in the gut by aiding the colonisation of pathogenic species and increasing the risk of IBD development

This is thought to occur through modulation of key signaling pathways like NF-B

Furthermore, in the case of breast cancer, an HSD has been found to promote tumor progression and lung metastasis, increase the proportion of Th17 cells, and activate the MAPK/ERK signaling pathway in breast cancer cells through the secretion of IL-17F

It can be used to address structural abnormalities, repair damaged cartilage, or remove bone spurs contributing to hip pain, providing long-term relief and improved joint function