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Sources conflict on the exact relationship: some describe fosgonimeton as a phosphate prodrug of Dihexa, while Athira has described a structurally distinct molecule so it is most accurate to call it the same program, structurally distinct, with conflicting public descriptions

Moreover, post-mortem studies of brains from AD patients indicate reduced expression of LRP-1 and increased RAGE (influx pump) expression, leading to a net increase of amyloid-beta influx into the brain [135]

-CAs are adopt a trimeric left-handed -helical architecture and utilize the same His 3 -H 2 O motif as -CAs (Figure 31C), but are reported to be Fe II -dependent enzymes that are also active with Zn II and Co II