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The findings of a large US real-world cohort (n= 18,000) study, published in 2024, show that patients on tirzepatide were significantly more likely to achieve 5 %, 10 % and 15 % weight loss compared with semaglutide (HR 1.76, 2.54, 3.24, respectively), with a 12-month mean weight difference of -6.9% 8

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Testosterone operates through androgen receptors throughout the body, influencing muscle protein synthesis, metabolic rate, and body composition distribution

However, the outcome can vary depending on individual factors such as diet and exercise