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Changes to gut microbiome in ALS include increased gut permeability and low levels of butyrate-producing bacteria [314, 315]

In addition, cyclic diGMP (c-di-GMP) is considered to be an anti-cancer adjuvant and which is a ligand for the interferon gene stimulator (STING) signaling pathway, when it was encapsulated in YSK05 liposome to form c-di-GMP/YSK05-Lip nanoparticles which can effectively induce the production of type I IFN and activate NK cells in mouse, and induce NK cell-mediated MHC-I non-restricted anti-tumor immunity to produce significant anti-tumor effects (89)

Schilperoort M, Ngai D, Sukka SR, Avrampou K, Shi H, Tabas I

doi: 10.1186/s43088-022-00196-1 28