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Authors are thankful for the support provided by the NIH grants R01HL142930 (KK) and R01HL132035 (XZ), a grant from the Pepper Older Americans for Independence Center (P30AG21332), and grants from the Department of Defense funding W81XWH-18-1-0118, W81XWH-19-1-0236, and R01AG018915 (HY), as well funds and services provided from the Center for Diabetes, Obesity and Metabolism, Wake Forest Baptist Medical Center, and the National Center for Advancing Translational Sciences (NCATS)