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In the context of personalized medicine, anti-obesity drugs play a crucial role in targeting and inhibiting the specific pathways involved in the pathogenesis of obesity

Following a second administration of Donor+Cas9, plasma Exe4 levels increased and remained elevated for over 28 weeks, doubling the level of Exe4 production and secretion compared to a single administration, suggesting the potential for fine-tuning the regimen dose through repetitive administration (Supplementary Fig