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CT-388 activates both GLP-1 and GIP receptors with a unique signaling profile: Signal-biased dual agonism: Potent cAMP signaling at both GLP-1R and GIPR Minimal to no beta-arrestin recruitment at either receptor Reduced receptor internalization and desensitization Potentially prolonged pharmacological activity GLP-1 receptor activation: Appetite suppression via hypothalamic and brainstem receptors Glucose-dependent insulin secretion Glucagon suppression Gastric emptying delay GIP receptor activation: Additional insulin sensitization Enhanced lipid metabolism Complementary appetite regulation Potential adipose tissue remodeling benefits The biased signaling mechanism is the key differentiator

The demand for GLP-1 drugs has surged in recent years for several reasons

Natural enhancement of these pathways through supplements appeals to those seeking proactive wellness without pharmaceutical interventions

The SIKis have yet to be tested on whole humans (not just loose patches of skin) to check for the effects of the drug leaking into the rest of the body, or discomfort from the drugs action on the skin