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Herein, we describe the discovery of the orally bioavailable, small-molecule, GLP-1R agonist PF-06882961 (danuglipron)
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For Providers Obesity management will increasingly extend beyond broad lifestyle modification advice or even pharmacologic intervention to encompass long-term weight maintenance and patient education on medication discontinuation and the potential for weight rebound
For those willing to accept this level of uncertainty, the risk-benefit calculation may still favor trying BPC-157, especially given its favorable safety profile and the limited options for chronic back pain sufferers
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