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The five most significant gene polymorphisms associated with endometriosis include interferon gamma ( IFNG ) (CA) repeat, glutathione S-transferase mu 1 ( GSTM1 ) null genotype, glutathione S-transferase pi 1 ( GSTP1 ) rs1695, and WNT4 rs16826658 and rs2235529 [99, 100]

192 Melatonin may also improve nocturia, a condition closely related to insomnia

The fact that stories about possible side-effects amongst some melanotan users are appearing in the media is a worry, and only serves to highlight the uncertainties around these injections and the need for proper studies

The clinical relevance of these results seems also highlighted by the evidence that for some outcomes the clinical benefit is consistent irrespective of the presence of type 2 diabetes [13], advanced age [13, 30], and the background cardiorenal disease [12, 15, 31]