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Physical activity, particularly through resistance and aerobic training modalities, catalyzes angiogenesis, augments endothelial functionality, and stimulates anabolic signaling cascades, thereby enhancing muscle protein synthesis (MPS) and metabolic adaptability (7, 8)

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Food and Drug Administration, Understanding Investigational Drugs , April 2, 2019 GoodRx, Retatrutide for Weight Loss: Availability, Dosage, and More , June 25, 2026 Food and Drug Administration, Expanded Access, accessed June 29, 2026 Eli Lilly, Expanded Access | Compassionate Use | Clinical Trials , accessed June 29, 2026 WBUR | Here & Now, An extraordinary new obesity drug is still awaiting FDA approval

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