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At the same time

APX activity, which catalyzes the reduction of H 2 O 2 using ascorbate, also showed a significant upregulation under stress

(33) demonstrated that transient receptor potential melastatin 4 (TRPM4) channels significantly contribute to oxidized low-density lipoprotein (ox-LDL)-induced dysfunction in human coronary artery endothelial cells (HCAECs)

Researchers found that a diet deficient in folate, B12, & B6 caused cognitive dysfunction and a significant reduction in the length & density of brain capillaries (9, 10)