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doi: 10.1038/s41598-018-36484-z 62 SinghS

For more information on micronutrients and phytochemicals related to cognitive decline or neurodegenerative diseases, see the article on Micronutrients for Older Adults

Methionine is an essential amino acid, and selenium is an antioxidant that acts as a cofactor for glutathione peroxidase which neutralizes hydrogen peroxide (see Figure 1)

3.4 GPX4-independent monitoring pathway By using gene suppression screening or CRISPR-Cas9 synthetic lethal screening, the Conrad and other research groups independently identified an important protein in ferroptosis, ferroptosis suppressor protein 1 (FSP1), which acted from a completely different thiol-dependent axis (Kim et al., 2001