Patients with genetic predispositions toward impaired fat oxidation or liver stress benefit most from lipotropic enhancement, enabling truly personalized GLP-1 protocols
33 Participants enrolled were receiving stable daily doses of one or two glucose-lowering drugs (metformin, sulfonylureas, SGLT-2 inhibitors, or thiazolidinediones)
Summary Keywords glutathione, oxidative stress, reactive oxygen species, nuclear factor erythroid 2-related factor 2, inflammaging, chronic obstructive pulmonary disease, atherosclerosis, COVID-19 Citation Labarrere CA and Kassab GS (2022) Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
Although direct clinical evidence of systemic NAD(P) depletion during GLP-1RA therapy is lacking, experimental and observational studies suggest that NAD turnover and micronutrient status can be altered in obesity and inflammatory states [83, 85], supporting the biological plausibility of substrate-sensitive vulnerability
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