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Garvey WT, Batterham RL, Bhatta M et al (2022) Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

Acknowledgements The authors are thankful to Chinese Government Scholarship (CSC) and National Natural Science Foundation of China for supporting our study and Yasir Islam and Abdullah Ahmad for their comments and critical reading of the manuscript

While GLP-1 can bind to receptors on circumventricular regions (e.g., area postrema), it is yet unclear to what extent gut-derived or brain-derived GLP-1 contribute to central GLP-1R activation (Trapp & Brierley, 2022)

In SURMOUNT-2 (adults with obesity/overweight and type 2 diabetes), tirzepatide achieved up to about 15.7% at 72 weeks