bryan johnson semaglutide I trialed micro dosing tirzepatide for its potential longevity benefits and it increased my RHR by 3 bpm. GLP-1RAs, such as semaglutide, liraglutide, and tirzepatide, elevate resting heart rate (RHR) by an Biotech CEO, 45, May Have

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Specifically, GLP-1RA administration downregulated the protein expression of haptoglobin, upregulated levels of PRKC apoptosis WT1 regulator (PAWR) and of synapsis-related proteins including synapsin-1, phosphodiesterase-2A (PDE2A), dihydropyrimidinase-like 2 (DPYSL2), neurofibromin-1, and microtubule-associated protein 1B (MAP1B), and increased neuronal and synaptic densities [59]

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doi:10.1016/j.celrep.2017.10.008