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Pharmacologically- or antibody-mediated inhibition of choline uptake favors diacylglycerol (DAG) accumulation and protein kinase C activation, resulting in altered cytokine secretion in response to LPS (70) ( Figure 3 )

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A prolonged period of observation and treatment for these symptoms may be necessary, taking into account the long half-life of RYBELSUS of approximately 1 week

Discussion Different modes of RCD have been observed in human MS (histo)pathology or suggested to contribute to MS pathology based on experimental models of monophasic EAE e.g