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DOI: 10.1093/humrep/deg366 11
In a joint 2014 letter, the agencies concluded that "A pooled analysis of data from 14,611 patients with type 2 diabetes from 25 clinical trials in the sitagliptin database provided no compelling evidence of an increased risk of pancreatitis or pancreatic cancer" and "Both agencies agree that assertions concerning a causal association between incretin-based drugs and pancreatitis or pancreatic cancer, as expressed recently in the scientific literature and in the media, are inconsistent with the current data
It is worth noting that the higher oxidation state of copper, Cu(III) may also shape the redox activation of the cytosolic copper pool and contributes to hydroxylation of phenolate substrates [60,61,62]
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