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Glutathione, with its glutamic acid and cysteine residues linked by a -amide bond, exhibits greater flexibility, characterized by a relatively shorter side chain, making it easier to extend into the dual copper-binding site and chelate with copper ions

removal of zymogen granules via the three-pronged strategy of centripetal dissolution, crinophagy and basolateral redirection

Kross and Scheer, 1991), and the ClO 2 prodrug NaClO 2 has also been approved as an ALS orphan drug by the European medicines agency (EMA) (EU/3/13/1139, 2024), and has demonstrated efficacy in a subset of ALS patients administered NaClO 2 intravenously in a Phase 2B clinical trial, notably reducing LPS levels in the blood which would suggest antimicrobial efficacy (Zhang et al., 2022)

Discovering the optimal combination of polyphenols for HNC, sustained by innovative delivery methods like liposomes and nanoparticles, could significantly benefit patients fighting this type of cancer worldwide