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It is the intricate regulation of expression of different isoforms of the ascorbate-glutathione pathway enzymes that helps in the maintenance of redox balance in plants under various abiotic and biotic stress conditions

10.1002/tox.23487 144 ZhangL.LiC.ZhangY.ZhangJ.YangX

This allows its N-terminal segment to penetrate the receptors transmembrane domain, while the C-terminal segment interacts with various receptor components, including the extracellular loops and the N-terminal -helix of the extracellular domain for both GLP-1 and GIP receptors

Flooding the system with high doses immediately can overwhelm these adaptive processes