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As a general principle, fewer ingredients means fewer unknown interactions, so a two-peptide blend involves less combinatorial uncertainty than a four-peptide one but that is not the same as being safe. A large, separate risk is product quality: these are unregulated research chemicals, and independent testing across the market has found mislabeled, underdosed, or contaminated products

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GLP-1 and exendin-4 transiently enhance GABAA receptormediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons