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Adding any substance to a sterile pharmaceutical vial introduces contamination risk, alters the pH and osmolality of the solution, and can potentially cause the semaglutide to precipitate or degrade

41 Despite its clinical significance, epidemiological research concerning DN is less extensive than other diabetic complications

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Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]