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Figure 7 The pathogenesis of OP, OA, and OSinvolves multiple factors and signaling pathways

Eryptosis is a physiological process, but uncompensated eryptosis may lead to anemia

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Tyrosinase exquisitely catalyzes two distinct reactions critical for the melanin synthesis: the hydroxylation of l-tyrosine (hydroxylate monophenols) to 3,4-dihydroxyphenylalanine (l-DOPA or ( o )ortho-diphenols) via a process named tyrosinase monophenolase activity and subsequently proceeds to process termed diphenolase activity, which causes oxidation of o -diphenols (l-DOPA) into o -quinones (DOPA quinone) 9,10,11