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Sehgal, Jena Shaw Tronieri, Lyle Ungar and Sharath Chandra Guntuku, 10 April 2026, Nature Health

Caroline Apovian, the co-director of the Center for Weight Management and Wellness at Brigham and Women's Hospital, agrees: "The studies show over and over and over again," Apovian says, that if you stop taking the medications, "you will regain the weight back." Noom isn't the only startup to market GLP-1s as temporary treatments that offer long-term effects

Its safety profile is well-established, with the most common side effects being mild gastrointestinal issues such as nausea, vomiting, and diarrhea

While alcohol is currently the primary focus, interest is expanding to other substance use disorders, including nicotine dependence and opioid use