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Biochem 46:776580, PMID: 17555331 Qanungo S, Starke DW, Pai HV, Mieyal JJ, Nieminen AL (2007) Glutathione supplementation potentiates hypoxic apoptosis by S -glutathionylation of p65-NFkappaB

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doi:10.1007/s12603-010-0330-4

FIGURE 9 5.3.5 ROS promotes UPS-mediated acceleration of protein degradation The ubiquitin-proteasome system (UPS) is the primary protein degradation machinery in eukaryotic cells, responsible for removing misfolded, damaged, or excess proteins to maintain proteostasis and regulate key cellular processes including cell cycle and immune signaling ( ROS indirectly accelerate UPS-mediated proteolysis by increasing intracellular calcium levels, activating calpains, and promoting cytoskeletal disassembly