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A couple of other considerations include gallbladder disease risk, rarely pancreatitis, and then there's a potential for loss of muscle mass with rapid weight reduction

Based on clinically available variables (BMI, waist circumference, OGTT/HOMA-IR, lipid profiles, NAFLD assessments, androgens, SHBG, and ultrasound markers), interpretable risk stratification models should be established rather than replacing clinical logic with black-box algorithms (173, 174)

A prescription-strength retinoid like tretinoin, which is available in multiple formulations, may be more effective at smoothing KP bumps

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