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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Western blot analysis revealed that sulforaphane alone did not obviously alter the expression of mTOR signalling components, but was highly resistant to the inhibition of phosphorylation of mTOR, p70S6K and 4E-BP1 by rotenone, in both the cerebral cortex and striatum (Fig