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Estrogen has also been reported to enhance transforming growth factor- (TGF-) signaling, which further contributes to osteoclast apoptosis and coupling between bone resorption and formation ( Studies related to runt-related transcription factor 1 (Runx1) and runt-related transcription factor 2 (Runx2) have increased the broadened our understanding of osteoblastic differentiation ( With advancing age, multiple tissues, including bone, undergo progressive structural and functional changes that contribute to organ dysfunction, and bone is no exception

Some people may also notice that alcohol or spicy foods make symptoms such as nausea, heartburn, or acid reflux worse, although tolerance varies from person to person