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Elevated levels of HSP27 and HSP70 in breast cancer cell lines are associated with increased resistance to doxorubicin, independent of P-glycoprotein (P-gp), a key mediator of multidrug resistance (MDR)

Although nNOS and eNOS are mainly expressed steadily in neurons and endothelial cells regardless of the cell's metabolic state, iNOS exists in trace amounts under healthy conditions and is synthesized de novo in some immunological cells, such as microglia, via inflammatory triggering (32)

Over time this causes thickening of the heart muscle, which causes it to pump less efficiently