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Patients with certain GLP1R rs6923761 genotypes may experience more rapid appetite suppression, while others show delayed or attenuated response, influencing both efficacy and side effect tolerance in the opening days

Furthermore, the data from a phase II study in participants with obesity and MASH presented at the American Diabetes Association showed those on survodutide achieved 18.7% mean weight loss after 46 weeks compared to the placebo group

Final verdict which compound to pick If youre starting fresh and you want maximum results with manageable side effects, tirzepatide is the stronger choice

Your body needs 2-4 weeks to upregulate fat-burning enzymes and adapt to lower glycogen availability