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any cloudiness may indicate aggregation or microbial contamination Visible particles or flocculation floating particles, fibres, or clumps are a clear sign the solution must not be used Discolouration any yellowing, browning, or colour change beyond the expected appearance described on the label warrants discarding the vial Gel-like consistency if the solution appears thicker than expected or does not flow freely, this may indicate peptide aggregation Do not open a sealed vial to assess odour

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