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The generation of Th2 cells is stimulated by IL-4 which is secreted by antigen-stimulated Th2 cells, but also by mast cells and basophils (176)

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Since embryos or infants produced through MRT carry maternal mtDNA, future studies should also focus on combining MRT with mtDNA gene editing to reduce mtDNA carriage to undetectable levels, providing potential directions for future research [138, 139]

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