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It also influences exocrine glandular function and thermoregulation through MC5 activation

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Smith MA, Makino S, Kvetnansky R, Post RM

In the foundational 2017 Cell study, naturally aged mice and chemotherapy-treated mice received FOXO4-DRI at 5 mg/kg by intraperitoneal (IP) injection , given on an intermittent schedule (about three times per week) across several weeks