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This direct pathway provides immediate substrate availability but faces limitations through arginase enzymes in the liver and intestines, which can metabolize significant portions of ingested l-arginine before reaching target tissues

Chronic diarrhea can also lead to dehydration, which increases the risk of constipation later on

On the other hand, MT2, being more potent, is often used for quicker and more intense tanning results, especially for individuals with lighter skin tones or those who require a rapid response to UV exposure

Both sites work well, and rotating between them is more important than which one you pick