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doi:10.1634/theoncologist.2013-0061 [DOI] [PMC free article] [PubMed] [Google Scholar] 50.Callander N, Markovina S, Eickhoff J, et al

TRPA1 current-voltage relationships were obtained by subtracting the background membrane current from the activated TRPA1 current under conditions in which there was a 1 V/s shift of the holding potential, applied as a linear voltage ramp

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Conventional delivery methods lead to systemic distribution rather than targeting specific tissues or cells under oxidative stress, reducing effectiveness and increasing the required dosage as reported by Sezgin-Bayindir et al