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There have been concerns about whether isotretinoin might affect growth, due to case reports of premature closure of the epiphyses (the growth areas at the ends of long bones) in the treatment of neuroblastoma, where much higher doses of this drug are given to younger children than what is typically prescribed for acne

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10 , 11 The gut microbiota modulates host metabolism via regulating various circulating metabolites, including bile acids and indoles

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