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For weight loss, tirzepatide acts centrally on appetite regulation centers in the hypothalamus, reducing hunger and increasing satiety signals

It is important to recognise that tiredness can arise from multiple factors, including the underlying condition being treated (type 2 diabetes itself), changes in eating patterns due to reduced appetite, gastrointestinal side effects affecting nutrition, or concurrent medications

In all three cases, the temporal relationship between injection and symptom onset was clear, with symptoms appearing within 24 hours and peaking at 48-72 hours

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