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Most available data comes from observational studies, post-hoc analyses, or research focused on metabolic outcomes in patients who happen to have coexisting inflammatory conditions

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Figure 2B focuses on direct and incretin-mediated signaling to the -cell, depicting how BefA, LPS and microbial tryptophan metabolites act on intestinal epithelial and enteroendocrine cells to modulate GIP and GLP-1 secretion and how these hormones, together with BefA, engage GIPR/GLP1R, cAMPPKA/EPAC2 and PI3K/AKT pathways to regulate -cell Ca 2+ influx, survival, proliferation and insulin granule exocytosis

Next, 6 10 6 cells (1 OD 600 (optical density at 600 nm) = 1 10 7 cells) were transferred into PBS with 0.1% BSA (PBS-B), containing 50100 M BP